Postdoctoral Associate – LbL Nanoparticle Systems for Delivery of Cytokine Proteins for Targeted Immuno-oncology:
This position in the Paula T. Hammond lab, at the Koch Institute of Integrative Cancer Research at MIT, will be filled by a biomaterials, chemical or biomedical engineer with strong materials science, biological and/or biomedical background and expertise in animal studies and histology. The project involves a collaboration with the Darrell J. Irvine lab, and will include joint interactions across labs. Background or interest in working with both in vivo and ex vivo tumor models such as organoids, and the use of high throughput methods to discover nanoparticle function and cell-material interactions is especially encouraged. This postdoctoral associate will examine the pharmacokinetics, biodistribution and modifications of the tumor microenvironment following delivery of combinations of different cytokines, with the potential to include additional therapeutics such as immunoregulators, to address advanced serous ovarian cancer. Broader sets of collaborations may also be possible within the Koch Institute Marble Center on Nanomedicine, including those involving combination therapy nanoparticle systems, theranostic systems, and the potential to explore other modes of immuno-oncology applications using nanomaterial systems.
Postdoctoral Associate – Multivalent Nano-conjugates for Targeted Penetration of and Delivery to Dense Extracellular Matrices (Cartilage, Cornea)
This position in the Paula T. Hammond Lab at the MIT Koch Institute and Dept. of Chemical Engineering, will be filled by a biomaterials scientist or engineer with chemistry, chemical engineering, materials science or bioengineering background. The project is a collaboration with the Alan Grodzinsky lab at MIT. The proposed work investigates new nanoscale carriers designed to penetrate densely charged, avascular tissues for biomedical applications including delivery of biologic and small molecule drugs to treat tissues such as cartilage, cornea, meniscus and tendon, that do not have blood vessels to help drug molecules get deep into the tissue for effective treatment. The work includes conjugation of nanocarriers such as dendrimers, with high positive charge valency, to achieve desired penetration and pharmacokinetics in joints, and optimization of conjugation chemistry to achieve triggered release in the presence of inflammation, pH/hypoxia, or enzymes. The work wil involve the release of biologic drugs and combinations with anti-inflammatory drugs that can aid in regeneration of cartilage (or other relevant drugs for treatment of cornea) and will be conjugated to the most optimal nanoparticle conjugates for delivery to cartilage to treat and aid in repair of early stage osteoarthritis in a highly controlled and effective manner. Collaboration opportunities within the Hammond lab on other drug nano-conjugates for tissue regeneration are also possible. Some expertise with synthetic polymer chemistry and/or chemical bioconjugation is preferred, as well as experience with in vitro cell work and materials characterization and bioanalytical methods.