PhD Student
Email: jtreese [at] mit . edu
she/her/hers
Nanoparticle delivery of STING peptide-polyanion conjugates as an ovarian cancer immunotherapy
The stimulator of interferon genes (STING) pathway has emerged as a therapeutic target due to its role in the cancer-immunity cycle. However, the loss of STING protein expression common in cancer cells can inactivate the pathway, rendering STING agonist immunotherapies ineffective. My research aims to engineer STING peptide-polyanion conjugates capable of activating the pathway in STING-deficient cells and leverage a nanoparticle delivery system to create a targeted immunotherapy for ovarian cancer treatment.