Visiting PhD Student
Email: palomarp [at] mit . edu
she/her/hers
Decoding the protein corona to improve drug delivery in ovarian cancer
Protein corona, a multilayered shell of biomolecules that spontaneously assembles on nanoparticle surfaces in biological fluids, critically defines how nanoparticles are trafficked and interact with biological systems. In my research, I investigate how distinct lipid nanoparticles acquire and dynamically remodel their protein corona following intraperitoneal administration in ovarian cancer models. By systematically mapping which endogenous proteins associate with specific nanoparticle surfaces, I aim to determine how specific corona components influence targeting within the peritoneal microenvironment, as well as cellular uptake and subsequent drug delivery. These studies provide a mechanistic framework for understanding corona-driven interactions and inform the design of nanoparticle systems to improve delivery outcomes.