Young Hoon Roh

 

Postdoctoral Researcher

RNAi Microsponges

RNA interference (RNAi) is powerful way for suppressing gene expression. In the gene silencing process by RNAi, double-stranded RNA (dsRNA) is processed to small interfering RNAs (siRNAs), which can mediate the cleavage of complementary target mRNA. Although siRNA mediated-gene silencing has been developed significantly, safe and effective intracellular delivery must be addressed to realize the full potential of siRNA therapeutics. Nucleic acids (DNA and RNA) have emerged as versatile polymers that can be utilized as a building block to build precisely controlled structures. With their biologically relevant functionality, self-assembled DNA or RNA structures are able to function as therapeutic agents for cancer treatment, viral infection and genetic diseases. Therefore, RNA particles encoding the sequences of small interfering RNAs (siRNAs) or micro RNAs (miRNAs) have great potential for RNA interference with precise control over the shape, size and composition. In the same passion of RNA particle, DNA particles can also be employed for gene or oligodeoxynucleotide (ODN) delivery. These rationally designed platforms make use of the particles for efficient drug delivery.

Email: yr36 @ mit . edu