Self-assembled drug carriers for disease management
My work is focused on applications involving self-assembled drug carriers for disease management, with a primary focus on cancer. In this work, I have been fortunate to team up with dedicated colleagues in Paula’s lab, as well as the labs of Joseph DeSimone at UNC-Chapel Hill, Michael Yaffe, Darrell Irvine, and Scott Floyd in the KI at MIT, Timothy Swager and Jeremiah Johnson in Chemistry at MIT, Katharina Ribbeck and Bevin Engleward in BE at MIT, and clinical collaborators, Alan D’Andrea and David Kozono, at the Dana-Farber Cancer Institute. With their support, I have worked on projects ranging from methods to understand the in vivo biological performance of various drug carriers (micelles, self-assembled polymeric carriers, liposomal systems), as well as strategies to promote targeted, multi-drug therapy for improved disease management – specifically, triple negative breast cancer, non-small cell lung cancer, glioblastoma, cancer immunotherapy, vaccines, and pneumonia.
The following publications feature some of this work:
S. W. Morton*, M. J. Lee*, Z. J. Deng, E. C. Dreaden, E. Siouve, K. E. Shopsowitz, N. J. Shah, M. A. Yaffe, P. T. Hammond. A Nanoparticle-Based Combination Chemotherapy Delivery System for Enhanced Tumor Killing by Dynamic Rewiring of Signaling Pathways. Science Signaling 2014, accepted.
S. W. Morton*, X. Zhao*, M. A. Quadir, P. T. Hammond. FRET-enabled biological characterization of polymeric micelles. Biomaterials 2014, 35, 3489.
S. W. Morton*, N. J. Shah*, M. A. Quadir, Z. J. Deng, Z. Poon, P. T. Hammond. Osteotropic therapy via LbL nanoparticles. Advanced Healthcare Materials 2013, early view.
S. W. Morton, K. P. Herlihy, K. E. Shopsowitz, Z. J. Deng, K. S. Chu, C. J. Bowerman, J. M. DeSimone, P. T. Hammond. Scalable Manufacture of Built-to-Order Nanomedicine: Spray-assisted Layer-by-Layer functionalization of PRINT® nanoparticles. Advanced Materials 2013, 25, 4706.
E. Ahmed*, S. W. Morton*, P. T. Hammond, T. M. Swager. Fluorescence multi-block π-conjugated polymeric nanoparticles for in vivo tumor targeting. Advanced Materials 2013, 25, 4504.
S. W. Morton, Z. Poon, P. T. Hammond. The architecture and biological performance of LbL nanoparticles. Biomaterials 2013, 34, 5328.