Simone Douglas-Green

Email: simoned [at] mit . edu

Dendrimer-Drug Conjugates for Cartilage Delivery and Penetration

Delivery of therapeutics to articular cartilage remains a challenge for drug delivery systems due to the avascular dense matrix and rapid clearance from the joint. After delivery, native proteins can adsorb to nanocarriers forming a nanocarrier-protein complex which affects their targeting and transport properties- this complex is part of the “true identity” of nanocarrier. My research focuses on characterizing these interactions for synovial joints and cartilage, as well as designing dendritic drug carriers with a biomimetic protein corona to improve residence time and cartilage penetration.