Designing novel block copolymer nanoparticles for drug delivery
Synthetic polypeptide block copolymers form stable, highly monodispersed assemblies, either in the form of polymersomes or micelles in selective solvents. Such assemblies are a facile, translatable and attractive platform for drug and gene delivery applications where the bioactive guest molecules can be either conjugated to the polymer blocks, or entrapped within the assembly core. These are essentially the new generation of liposome mimetics with more structural amenability. We are generating block copolymers of diversified molecular architectures based on natural polypeptide motifs, which self-assemble into nanoparticles of defined size. Using an orthogonal functionalization approach, environment sensitive modalities and disease-specific ligands are added on to these nanoparticles for sensing specific pathological cues. Utilizing these novel block copolymeric nanoparticles as model drug delivery systems, we are investigating the effect of ligand stoichiometry, localization and clustering on cell-interaction for designing advanced therapeutic soft materials.
Email: maquadir @ mit.edu