SMART Antimicrobial Resistance, Singapore
Email: michelle.turvey [at] smart . mit . edu
Layer-by-layer Nanoparticles for the Delivery of Antimicrobials
Antimicrobial polymers can potentiate the activity of antibiotics towards otherwise drug-resistant Gram-negative bacteria. The research of the SMART group in Singapore focuses on the development of therapeutic nanoparticle systems for the localized co-delivery and temporally controlled release of synergistic combinations of antimicrobial polymers and antibiotics. Layered nanoparticles are constructed with an enzyme-responsive outer layer designed to trigger particle disassembly at the site of infection, first releasing a cationic amphiphilic antimicrobial polymer that weakens bacterial defenses by disrupting membrane integrity, with subsequent release of antibiotic loaded in the liposomal core to effect complete bacterial killing.