Email: msofman [at] mit . edu
Development of 3D Microvascular Environments for Cell Systems Using Synthetic Biomaterials
Three-dimensional in vitro tissue and organ cultures are of increasing interest as models for human disease and drug development. My research focusses on developing and characterizing polymer biomaterials that engage with cells at the material interface in order to guide specific functional morphogenetic events that can enhance in vitro tissue culture models. A specific application focus is to engineer a vascularized tissue construct using a polymer microbead angiogenesis scaffold that is capable of promoting invasion of endothelial cells into a dense epithelial tissue.