Brett Geiger

Email: bgeiger [at] mit . edu



Injectable Polymeric Nanoparticles for Cartilage Loss Prevention

Traumatic joint injury, such as a torn ligament, increases the risk of local cartilage degradation and the long term development of osteoarthritis.  Once articular cartilage is destroyed, it is very difficult to repair or replace. My research is focused on preventing cartilage loss by developing polymeric nanoparticles capable of penetrating cartilage and acting as release depots for biologic drugs such as Insulin-like Growth Factor 1 (IGF-1).  These particles are to be injected directly into a joint after injury to prevent cartilage degradation and the onset of osteoarthritis.