In Situ Cell & Fluid Sampling Using Alternative Immune Monitoring Systems
Immune monitoring methods are currently confined to enumeration of types of cells contained in mainly blood, cerebrospinal fluid or other body fluids obtained from invasive sampling and biopsies. Even these are indirect indicators of the status of the immune system as immune cells mainly reside in the lymphatic system. The only current test that involves direct interrogation of the immune system is by delayed type hypersensitivity tests (Mantoux tuberculin test) which also lack information about functional characteristics and phenotype of immune cells. I am developing technologies addressing these challenges together, with the synergistic goals of providing enhanced diagnostic methods for sampling and analyzing the function of the immune system that provide greater insight into the status of the immune system than any assays currently available.