Synthetic biopolymers from a modular peptide scaffold
Natural biopolymers are rich in functionality and utility, but are often difficult to reproducibly isolate in sufficient quantities. A specially designed synthetic polymer has the potential to replicate a natural material and may be synthesized on an industrial scale with minimal batch to batch variability. I have developed a synthetic polypeptide with pendant “click” groups, which enable efficient conjugation of small molecules and other polymers. I am currently synthesizing biomimetic glycopeptides from this polymer scaffold and probing how the architecture and chemical composition of these synthetic polymers influence their interaction with cells.
Email: wangwade @ mit . edu