Layer-by-layer Nanoparticle Design for Enhancing Uptake by Ovarian Cancer Cells
Efficient delivery of nanotherapeutics face a number of systemic, intratumoral, and intracellular barriers in vivo. Often, nanoparticle delivery and uptake at the site of tumors is insufficient to see therapeutic efficacy of encapsulated cancer therapeutics. Enhancing targeted delivery of nanoparticles is particularly relevant for cancers with high levels of metastases. My work specifically focuses on understanding the fundamental effects of nanoparticle architecture and chemistry on delivery to High Grade Serous Ovarian Cancer(HGSOC) tumors. This will aid and inform the design of layer-by-layer nanoparticles for optimal trafficking properties.
Email: kong94 [at] mit . edu