Our lab has developed approaches around the incorporation of surface-erodible, hydrolytically degradable components in coatings for sequential or simultaneous multi-drug release. These advances led to the controlled release of proteins and biologic factors from conformal coatings of implants and scaffolds that yield physiologically relevant amounts delivered locally over extended periods of up to multiple weeks. Very recent results from our research group indicate the success of delivery of bFGF, BMP-2, VEGF and PDGF, as well as nucleic acids such as plasmid DNA and siRNA. We have applied electrostatic layer-by-layer and other polymer self-assembly processes toward biomaterials for applications that include tissue engineering and wound healing, including diabetic ulcer wound healing, soft tissue wounds and antifibrotic healing processes. By directly incorporating siRNA to knockdown specific proteases, we have also shown the promise of nucleic acid delivery directly to wound sites, and the use of DNA as a vaccine delivered with microneedle technology.