Craniomaxillofacial (CMF) surgery is required to address congenital birth defects and traumatic injuries to the face and jaw. CMF reconstruction is one of the most challenging areas for bone regeneration, as it requires modulated repair that leads to tissue regeneration while maintaining or recapitulating facial structure. To fill this clinical gap, the Hammond lab has pioneered electrostatic layer-by-layer (LbL) coatings to deliver pro-healing growth factor proteins from implanted tissue engineering scaffolds to enhance bone regeneration. My research aims to engineer environmentally-responsive drug release systems into these LbL assemblies so that pro-healing therapeutics are delivered “on-demand” in response to new tissue growth and cellular activity. This strategy will create biomaterial implants that can generate a more favorable healing response in patients with critically-sized CMF bone defects.
Email: jrmart [at] mit . edu