My research directions are two-fold: (a) I am developing synthetic materials (e.g. polycations and cationic liposomes) to fine tune the assembly of macromolecule complexes including proteins and nucleic acids to modulate their biological functions; (b) I recently pioneered a pre-assembly strategy to deliver ribonucleoproteins (protein/RNA complexes) to enhance the efficacy of mRNA- and siRNA-based biologics. This could have implications in the treatment of numerous diseases with mRNA vaccines and/or siRNA inhibitors.
Email: jiaheli [at] mit . edu