Designing poly-siRNA Nanoparticles for Cancer Therapy
The use of synthetic small interfering RNA (siRNA) to silence the expression of specific genes via the RNA interference mechanism is highly promising for cancer therapy. However, the successful and efficient delivery of siRNA remains a difficult challenge. The self-assembly of polymerized siRNA (poly-siRNA) into RNA microsponges has recently been demonstrated. Complexation of the poly-siRNA with cationic polymers can yield polyplexes of much greater stability than siRNA polyplexes. We are interested in designing poly-siRNA systems that can be delivered to cells at high efficiencies and undergo controlled intracellular release. Incorporating poly-siRNA as the basis for LbL nanoparticles will potentially enable a highly effective combination drug cancer therapy.
Email: conniewu [at] mit . edu