LbL Coated Microneedles for Vaccine Delivery
Polymeric microneedle arrays are a promising platform for vaccine delivery since they can potentially be stored at room temperature whereas injectable vaccines need to be refrigerated while en route to their destination. Further, microneedle applications have been shown to be significantly less painful than typical injections, and these arrays do not necessarily need to be administered by trained personnel. By using microneedles to deliver alternating layers of biodegradable, cationic polymers and anionic vaccine components to the immune cells in the skin at controlled rates for prolonged periods of time, we aim to induce robust immune responses.
Email: zmolek @ mit . edu